Package:1 vial (450mg/ml 10 ml)
Active Substance: 

Testosterone Acetate – 32mg;

Testosterone Decanoate – 147mg;

Testosterone Propionate – 73mg;

Testosterone Phenylpropionate – 73mg;

Testosterone Cypionate – 125mg

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Supertest 450 from SP-Laboratories is administered in men to treat androgenic deficit after castration, eunuchoidism, hypopituitarism, hormone-induced impotence, male climacteric symptoms (decreased libido and physical and intellectual activity), and some forms of infertility with impaired spermatogenesis. It is also used to treat osteoporosis caused by androgen insufficiency. In women, Supertest 450 is utilized to treat high levels of estrogen, uterine myoma, endometriosis, breast cancer, and osteoporosis.


Supertest 450 is not indicated for use in individuals with hypersensitivity to the drug, prostate and breast carcinoma, prostate hyperplasia with urination disorders, nephrosis or nephrotic phase of nephritis, edema, hypercalcemia, liver function disturbances, diabetes, heart failure or coronary disease, myocardial infarction, and atherosclerosis in elderly men. It is also contraindicated during pregnancy and lactation.


Supertest 450 is administered by deep intramuscular injection. The dosage is determined individually based on the indication and the patient’s response.

Typically, adults receive 1 ml intramuscularly once every 14 days. When a therapeutic effect is achieved, the dosage is reduced to 1 ml intramuscularly once every 28 days. The duration of treatment is determined on an individual basis.

For male sterility (azoospermia, oligospermia), the dosage is 2 ml once every 2 weeks (treatment is discontinued if painful erections occur).

In breast cancer in women, the dosage is 1-2 ml every 1-2 weeks during the treatment period.

The drug must not be administered intravenously.

Medical action:

Supertest 450 comprises a blend of testosterone esters (propionate, phenylpropionate, isocaproate, and decanoate).

Testosterone is the primary androgen hormone synthesized and released by the testes. It is responsible for the growth and development of male sex organs and secondary sexual characteristics, such as the maturation of the prostate, seminal vesicles, penis, and scrotum, as well as male hair distribution (face, groin, chest), development of laryngeal muscles, and body fat distribution. Testosterone retains nitrogen, sodium, potassium, and phosphorus, increases anabolism, and decreases protein catabolism. Premature increases in serum testosterone during the prepubertal period can cause stunted growth and epiphyseal closure. Testosterone stimulates the production of red blood cells and erythropoietin and inhibits the pituitary secretion of luteinizing hormone and follicle-stimulating hormone, leading to suppression of spermatogenesis.

In women, Supertest 450 inhibits pituitary gonadotropic function, ovarian function, and mammary glands, leading to endometrial atrophy. Due to its antagonistic action against estrogen, it is useful in treating uterine myoma, endometriosis, and breast cancer. It also manifests beneficial effects during the climacteric period.


If androgen-dependent adverse reactions occur, it is necessary to discontinue the medication. After the disappearance of adverse reactions, treatment may be resumed at lower doses.

Patients with latent or overt cardiac failure, impaired renal function, hypertension, epilepsy, or migraine (or a history of these conditions) must be under constant supervision due to the possibility of sodium and water retention caused by androgens. Liver function should be monitored during long-term treatment. In patients with breast cancer, hypernephroma, lung cancer, or bone metastases, calcium levels in blood and urine need to be controlled. In prepubertal adolescents, the drug should be administered cautiously to avoid stunted growth and premature puberty.

Side effects:

  • Priapism and other symptoms of sexual hyperstimulation (frequent erections);
  • Accelerated sexual development in prepubertal teenagers, increased frequency of erections, increased size of sexual organs, and premature epiphyseal closure;
  • Impaired spermatogenesis and sperm maturation disorders, oligospermia, and reduced ejaculate volume;
  • Prostate abnormalities;
  • In women, bleeding from the genital tract, increased libido, and possible virilization symptoms with prolonged administration;
  • Hirsutism, gynecomastia;
  • Seborrhea, acne, oily skin, hair loss;
  • Water and sodium retention, edema;
  • Symptoms of hypercalcemia;
  • Thrombophlebitis;
  • Nausea, cholestatic jaundice, increased liver transaminase levels (which normalize upon discontinuation);
  • Headaches, depression, aggression, anxiety, sleep disorders, paresthesias, and possible pain, itching, and redness at the injection site.


In the event of an overdose, seek immediate medical assistance.


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