Package: 100 tabs (20mg/tab)

Active Substance: Tadalafil

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Esculap, commonly known by its generic name Tadalafil and produced by Balkan Pharmaceuticals, is an oral medication primarily used to treat erectile dysfunction (ED). It is also prescribed for conditions like benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension (PAH). Tadalafil belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. This comprehensive guide will delve into the indications, contra-indications, administration, medical action, precautions, side effects, overdosage, and conclusion regarding Esculap, providing a thorough understanding of its uses and effects.


Esculap is primarily indicated for the treatment of erectile dysfunction (ED) in men, a condition where achieving or maintaining an erection suitable for sexual activity is difficult. Tadalafil helps by enhancing blood flow to the penis, thereby facilitating an erection when sexually stimulated. Additionally, it is used to treat benign prostatic hyperplasia (BPH), a condition characterized by an enlarged prostate gland causing urinary difficulties. Esculap is also prescribed for pulmonary arterial hypertension (PAH), where it helps relax blood vessels in the lungs, reducing the workload on the heart.


Esculap is not suitable for everyone. It is contraindicated in individuals who are taking nitrates, commonly prescribed for chest pain, as the combination can lead to a dangerous drop in blood pressure. It is also not recommended for those with severe cardiovascular conditions, including recent heart attack or stroke, severe hypotension, or uncontrolled hypertension. Individuals with a history of priapism (prolonged and painful erection) or anatomical deformation of the penis should avoid Tadalafil. Additionally, those with severe liver or kidney disease should use this medication with caution and under strict medical supervision. Consulting a healthcare professional before starting Esculap is essential to ensure its safety based on your health history and current condition.


Esculap is administered orally, typically in tablet form. For erectile dysfunction, the recommended starting dose is 10 mg taken prior to anticipated sexual activity. Depending on efficacy and tolerability, the dose may be adjusted to 20 mg or reduced to 5 mg. It can also be taken as a daily dose of 2.5 mg to 5 mg for those who anticipate frequent sexual activity (at least twice weekly). For benign prostatic hyperplasia, the usual dose is 5 mg taken once daily. When used for pulmonary arterial hypertension, the prescribed dosage varies, and it is crucial to follow the healthcare provider’s instructions meticulously. Tadalafil can be taken with or without food, but it is important to adhere to the prescribed dosage to avoid potential side effects.

Medical Action

Tadalafil, the active ingredient in Esculap, works by inhibiting the enzyme phosphodiesterase type 5 (PDE5). This inhibition increases the levels of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells, leading to relaxation and increased blood flow. In the context of erectile dysfunction, this action helps achieve and maintain an erection. For benign prostatic hyperplasia, the relaxation of smooth muscle in the prostate and bladder improves urinary symptoms. In pulmonary arterial hypertension, the dilation of pulmonary blood vessels reduces pulmonary blood pressure and eases the heart’s workload. This multifaceted action makes Tadalafil a versatile drug for several conditions.


Before starting Esculap, a thorough medical evaluation is necessary. Regular monitoring of blood pressure and heart function is recommended, especially in individuals with cardiovascular conditions. Patients should inform their healthcare provider about any other medications they are taking, as Tadalafil can interact with certain drugs, particularly nitrates, alpha-blockers, and antihypertensives. It is also important to avoid excessive alcohol consumption while taking Tadalafil, as it can increase the risk of side effects such as dizziness or low blood pressure. Adopting a healthy lifestyle, including a balanced diet and regular exercise, can help mitigate some of the risks associated with Tadalafil.

Side Effects

Like any medication, Esculap can cause side effects. Common side effects include headaches, flushing, indigestion, nasal congestion, back pain, muscle aches, and dizziness. These symptoms are usually mild and tend to diminish with continued use as the body adjusts. More serious side effects, though rare, can include sudden hearing or vision loss, chest pain, shortness of breath, and priapism (a prolonged and painful erection lasting more than four hours). If any severe or persistent side effects occur, it is important to seek medical attention immediately. Regular follow-ups with a healthcare provider are crucial to monitor for any adverse effects and to adjust the treatment plan as needed.


An overdose of Esculap can lead to significant health complications. Symptoms of overdose may include severe dizziness, fainting, painful or prolonged erection, and other serious cardiovascular effects. If an overdose is suspected, it is crucial to seek emergency medical help immediately. Treatment typically involves supportive care, including monitoring of vital signs and administration of medications to counteract the effects of the overdose. Adhering strictly to the prescribed dosage and administration guidelines can prevent the risk of overdose and associated health risks.


Esculap (Tadalafil) from Balkan Pharmaceuticals is a versatile oral medication with significant applications in treating erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Its ability to enhance blood flow and relax smooth muscles makes it an invaluable tool for improving the quality of life in affected individuals. However, it is essential to use Esculap responsibly and under the supervision of a healthcare professional. Understanding the indications, contra-indications, proper administration, and potential side effects can help users maximize the benefits while minimizing risks. Always consult with a healthcare provider before starting any new medication to ensure it is appropriate for your individual health needs.

By following these guidelines and maintaining regular medical check-ups, individuals can safely and effectively incorporate Esculap into their treatment regimen to achieve their desired health outcomes. Whether it is improving erectile function, alleviating urinary symptoms associated with BPH, or managing pulmonary hypertension, Tadalafil offers a reliable and effective solution.


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