Package: 100 tabs (20mg/tab)

Active Substance: Isotretinoin

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Accutane, also known as Isotretinoin, is a powerful oral medication produced by Dragon Pharma, primarily used for the treatment of severe acne. This guide will cover all aspects of Accutane, including its indications, contraindications, administration, medical action, precautions, side effects, overdosage, and conclusion.


Accutane is primarily indicated for the treatment of severe recalcitrant nodular acne. This type of acne is characterized by large, painful, and inflamed nodules and cysts that can cause significant scarring and emotional distress. When conventional treatments such as topical medications and oral antibiotics fail to provide relief, Accutane is often prescribed as a last resort.

In addition to treating severe acne, Accutane has been used off-label for other dermatological conditions, including rosacea, severe psoriasis, and some rare skin cancers. However, its primary use remains the treatment of severe acne that does not respond to other therapies.


While Accutane offers significant benefits, it is not suitable for everyone. Several contraindications should be considered before using this drug:

  • Pregnancy and Breastfeeding: Accutane is highly teratogenic, meaning it can cause severe birth defects if taken during pregnancy. Women who are pregnant or planning to become pregnant must not use this medication. Additionally, it is contraindicated for breastfeeding women due to the potential for serious adverse effects on the infant.
  • Liver Disease: Individuals with severe liver dysfunction or liver disease should not use Accutane as it can exacerbate liver issues.
  • Hyperlipidemia: Patients with high levels of fat in their blood (hyperlipidemia) should avoid Accutane, as it can further increase lipid levels.
  • Allergy to Isotretinoin or its Components: Those with a known allergy to Isotretinoin or any of its components should not use this drug.

Patients with a history of severe depression or other mental health issues should use Accutane with caution, as it has been associated with mood changes and other psychological effects.


Accutane is administered via oral capsules. The typical dosage for severe acne ranges from 0.5 to 1 mg per kilogram of body weight per day, divided into two doses. The treatment duration typically lasts 15 to 20 weeks, depending on the response and the severity of the acne.

For optimal results, it is essential to take Accutane with food to enhance its absorption. Consistency in taking the medication at the same time each day is also important to maintain stable blood levels of the drug. Patients should follow their healthcare provider’s instructions closely and not alter the dosage or duration of treatment without consultation.

Medical Action

Accutane, or Isotretinoin, works by reducing the size and activity of the sebaceous (oil) glands in the skin, which decreases oil production. Excessive oil production is one of the primary factors that contribute to the development of severe acne. By reducing oil production, Accutane helps to prevent clogged pores and the formation of acne lesions.

Additionally, Accutane promotes the turnover of skin cells and reduces inflammation, further aiding in the treatment of acne. Its ability to shrink the sebaceous glands and reduce sebum production makes it particularly effective for treating severe, stubborn acne that does not respond to other treatments.

Accutane’s potent effects on the skin can lead to significant improvement in acne severity and appearance, often resulting in long-lasting remission even after the treatment has ended.


Before starting Accutane, it is essential to undergo a thorough medical evaluation. This includes blood tests to assess liver function, cholesterol levels, and overall health status. Women of childbearing potential must have a negative pregnancy test before starting treatment and must use effective contraception during treatment and for at least one month after discontinuing Accutane.

Patients should inform their healthcare provider of any pre-existing medical conditions, allergies, or medications they are taking to prevent potential drug interactions and complications. It is crucial to monitor lipid levels and liver function regularly during treatment, as Accutane can affect these parameters.

Maintaining a healthy lifestyle, including a balanced diet and proper hydration, is important while using Accutane. Patients should avoid excessive sun exposure and use sunscreen, as Accutane can increase skin sensitivity to UV rays.

Side Effects

Like any potent medication, Accutane can cause side effects. Common side effects include:

  • Dry Skin and Lips: Accutane often causes dryness and peeling of the skin and lips, which can be managed with moisturizers and lip balms.
  • Nosebleeds: The drying effect of Accutane on the nasal passages can lead to nosebleeds.
  • Joint and Muscle Pain: Some users report joint and muscle pain during treatment.
  • Eye Irritation: Dry eyes and irritation can occur, often requiring the use of artificial tears.
  • Mood Changes: Accutane has been associated with mood changes, depression, and anxiety in some individuals.
  • Liver Function: Elevated liver enzymes may occur, indicating liver stress.

Less common but more serious side effects include severe skin reactions, vision changes, and pancreatitis. If any severe side effects occur, it is crucial to seek medical attention immediately. Adjusting the dosage or discontinuing the use of Accutane may be necessary to mitigate adverse effects.


An overdose of Accutane can lead to severe health complications. Symptoms of overdose may include severe headache, dizziness, vomiting, stomach pain, and swelling of the lips and mouth. In extreme cases, an overdose can cause life-threatening conditions such as liver damage or pancreatitis.

If an overdose is suspected, it is essential to seek emergency medical assistance. Treatment typically involves supportive care and monitoring of vital signs. In some cases, medications may be administered to counteract the effects of excess Isotretinoin.


Accutane from Dragon Pharma is a powerful medication that offers significant benefits for the treatment of severe acne. Its unique ability to reduce oil production and promote skin cell turnover makes it highly effective in clearing up stubborn acne that does not respond to other treatments. By understanding the indications, contraindications, administration, medical action, precautions, side effects, and potential for overdosage, users can make informed decisions about using Accutane.

While Accutane can provide dramatic improvements in acne severity and overall skin appearance, it is crucial to use this medication responsibly and under the guidance of a healthcare provider. Regular monitoring and adherence to recommended dosages help to minimize the risk of side effects and ensure optimal results.

Accutane’s impressive ability to promote long-lasting acne remission makes it a popular choice among dermatologists and patients seeking to improve their skin health and quality of life. As with any potent drug, responsible use and thorough understanding of its effects are essential to achieving the best possible outcomes.


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